Tirzepatide
The dual GIP/GLP-1 behind Mounjaro and Zepbound — often the strongest option.
What tirzepatide actually is
Tirzepatide acts on two gut hormones (GIP and GLP-1) rather than one, and in head-to-head trials it tends to produce more weight loss than semaglutide. It’s the active ingredient in Mounjaro and Zepbound, and — like semaglutide — is widely offered as a compounded injection at med spas.
A good fit if…
- You qualify for medical weight loss and want a strong option
- Semaglutide stalled or wasn’t enough for you
- You want ongoing medical monitoring
Maybe not for you if…
- You’re pregnant, breastfeeding, or planning pregnancy soon
- You have a history of medullary thyroid cancer or MEN2
- You can’t commit to follow-up and lifestyle changes
Find vetted tirzepatide providers
We rank providers on real ratings and review volume, then mark the ones our editors reviewed. Choose your city:
Common questions
Is tirzepatide better than semaglutide?
On average it produces more weight loss in trials, but “better” depends on your response, tolerance, and cost. Many people do well on either — a provider helps you choose and adjust.
What does it cost?
Compounded tirzepatide programs at med spas often run $300–$600 a month; brand-name Zepbound or Mounjaro is priced differently. Confirm what’s included before you start.
Are the side effects different?
Similar profile to semaglutide — mostly GI symptoms early on that tend to settle with gradual dosing. Screening and follow-up are the safeguards.